Department of Drosophila Genomics and Genetic Resources Center for Advanced Insect Research Promotion
Kyoto Institute of Technology
Saga Ippongi-cho, Ukyo-ku, Kyoto 616-8354, Japan
Phone: 075-873-2660
Facsimile: 075-861-0881


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SGU - DGGR Workshop

Posted in News English,センター活動,教育・研究 on October 02,2015

DateOctober 15th - 16th, 2015,
LocationDept. Drosophila Genomics and Genetic Resources at Saga campus
PresenterDr. Brian Oliver
Laboratory of Cellular and Developmental Biology
Title "Functional Genomics"
Abstract We have learned a great deal about the logic of development and disease by studying transcription over the last several decades. The techniques have evolved from analysis of expression of single genes to rapidly evolving genome-wide techniques. We will focus on next generation sequencing and discuss elements of experimental design, the use of exogenous RNAs of known concentration as internal standards, and computational null models using simulations. There are many applications for expression analysis. These include the use of expression data for genome annotation to identify UTR extensions, novel exons, and novel genes, especially in the male transcriptome. Not every segment of transcribed DNA is functional. Operating under the assumption that functional elements will show conserved expression in the genus, we will illustrate the value of comparative gene expression profiling used to determine if novel transcribed segments in D. melanogaster were functional. Gene expression profiles are a molecular phenotype. We will discuss using expression phenotypes to address genome-wide questions, particularly about the nature and evolution of gene content and dosage compensation due to sexual selection, and as a valuable tool for building genetic pathways.
ChairpersonTim Karr

For more infomation, contact: Takano, Toshiyuki
Dept. Drosophila Genomics and Genetic Resources
Tel. 075-873-2660
Please contact from this form.