Yoshihiro H. Inoue

Email: yhinoue@kit.ac.jp

Research Interests:

Cell cycle, Cell divisions, Chromosome structure

Recent Publications:

  • Inoue Y. H., Savoian, M., Suzuki, T., Yamamoto, M. and Glover, D. M. : Mutation in orbit/mast, reveal that the central spindle is comprised of two microtubule populations; those that initiate cleavage and those that propagate furrow ingression. J. Cell Biol. 116:1-12, 2004
  • Yamaguchi M, Hirose F, Inoue Y. H, Ohno K, Yoshida H, Hayashi Y, Deak P and Matsukage A.: Genetic link between p53 and genes required for formation of the zonula adherens junction. Cancer Sci. 95:436-41, 2004
  • Takata, K, Inoue, Y. H., Hirose, F., Murakami, S., Shimanouchi, S., Sakimoto, I., and Sakaguchi, K. : Spatio-temporal expression of Drosophila mitochondrial transcription factor A during development. Cell Biology International 27:361-374, 2003
  • Mathe, E., Inoue, Y. H., and Glover, D. M. : Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions anddevelopment of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis. Development 130: 901-915, 2003
  • Higashiyama, H., Hirose, F., Inoue, Y. H., Fujikake, N., Matsukage, A. and Kakizuka, A. Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration. Cell Death and Differentiation 2002 9: 264 -273.
  • Yamaguchi, M., Yoshida, H., Hirose, F., Inoue, Y. H., Hayashi, Y., Yamagishi, M., Nishi, Y., Tamai, K., Sakaguchi, K., and Matsukage, A. Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosis. Chromosoma. 2001 110: 313-321.
  • Yoshida, H., Inoue,Y.H., Hirose, F., Sakaguchi, K., Matsukage, A., Yamaguchi, M. Overexpression of DREF in the Drosophila wing imaginal disc induces apoptosis and a nothching wing phenotype. Genes Cell 2001 6: 1-11.
  • Hirose, F., Ohshima, N., Inoue, Y. H., Taguchi, O., Nishi, Y., Matsukage, A. and Yamaguchi, M. Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins. Mol. Cell. Biol. 2001 21: 7231-7242.
  • Yamaguchi M., Hirose F., Inoue Y. H., Hayashi Y., Nishi Y., and Matsukage A. Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc. Oncogene 2000 18: 6767-6775
  • Ohno, K., Takahashi, Y., Hirose, F., Inoue, Y. H., Taguchi, Y., Nishida, Y., Matsukage, A and Yamaguchi, M. Characterizatiion of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF) Gene 2000 260: 133-143
  • Oshige, M., Yoshida, H., Takata, K., Inoue, Y. H., Aoyagi, N., Yamaguchi, M., Matsukage, A. and Sakaguchi, K. Molecular cloning and expression during development of the Drosophila gene for the catalytic subunit of DNA polymerase. Gene 2000 256: 93-100
  • Inoue Y. H., do Carmo Avides, M., Shiraki , M., Deak P., Yamaguchi M., Nishimoto Y., Matsukage A., Glover D.M. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila. J. Cell Biol. 2000 149:153--165.
  • Lim, Y.M., Nishizawa, K., Nishi, Y., Tsuda, L., Inoue, Y.H. , Nishida, Y. Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase. Genetics 1999 153(2):763--771
  • Yamaguchi, M., Hirose, F., Inoue, Y.H., Shiraki, M., Hayashi, Y., Nishi, Y., Matsukage, A. Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc. Oncogene 1999 18(48):6767--6775
  • Ohno, K., Hirose, F., Inoue, Y.H., Takisawa, H., Mimura, S., Hashimoto, Y., Kiyono, T., Nishida, Y., Matsukage, A. cDNA cloning and expression during development of Drosophila melanogaster MCM3, MCM6 and MCM7. Gene 1998 217(1-2):177--186
  • Inoue, Y.H., Glover, D.M. Involvement of the rolled/MAP kinase gene in Drosophila mitosis: interaction between genes of the MAP kinase cascade and abnormal spindle. Molec. gen. Genet. 1998 258(4):334--341
  • Lim, Y.M., Tsuda, L., Inoue, Y.H., Irie, K., Adachi-Yamada, T., Hata, M., Nishi, Y., Matsumoto, K., Nishida, Y. Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades. Genetics 1997 146(1):263--273
  • Nishida, Y., Inoue, Y.H., Tsuda, L., Adachi-Yamada, T., Lim, Y.M., Hata, M., Ha, H.Y., Sugiyama, S. The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila. Cell Struct. Funct. 1996 21(5):437--444
  • Sawamura, K., Fujita, A., Yokoyama, R., Taira, T., Inoue, Y.H., Park, H.S., Yamamoto, M.T. Molecular and genetic dissection of a reproductive isolation gene, zygotic hybrid rescue, of Drosophila melanogaster. Jpn J. Genet. 1995 70(2):223--232
  • Hata, M., Inoue, Y.H., Yoo, M.A., Nishida, Y. Multiple functions of raf proto-oncogene during development from analysis of a temperature-sensitive mutation of Drosophila. Int. J. Dev. Biol. 1994 38(2):329--335
  • Tsuda, L., Inoue, Y.H., Yoo, M.A., Mizuno, M., Hata, M., Lim, Y.M., Adachi, T., Ryo, H., Masamune, Y., Nishida, Y. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 1993 72(3):407--414
  • Gamo, S., Sakajo, M., Ikeda, K., Inoue, Y.H., Sakoyama, Y., Nakashima-Tanaka, E. Temporal distribution of P-elements in Drosophila melanogaster strains from natural populations in Japan. Jpn J. Genet. 1990 65:277--285

Reviews:

  • Inoue, Y. H. Chromosome segregation in animal cells. (Akio Matsukage and Hisao Masai ed.) Springer-Verlag Tokyo. (in Japanese)
  • Lynne S. Cox, Y. H. Inoue Okazaki fragment processing during eukaryotic DNA replication. Jikken Igaku 1998 16 1031-1042 (in Japanese)
  • Inoue, Y. H. Saibou bunka no kettei to shigunaru dentatu kikou Jikken Igaku Tokushuu: Saibou bunka no kettei kikou 1992 10: 888-893 (in Japanese)

Books:

  • Inoue, Y. H. and Yasuyoshi Nishida: Analysis of gene transcription using transgenic Drosophila. (Syunji Natori ed.) Hirokawa-shoten (in Japanese)
  • Inoue, Y. H. and Nishida, Y. Protein Kinase Facts Book. In :D. G. Hardie, (eds.), DIR (Drosophila insulin receptor homolog): Academic Press Ltd., 1992

Last modified at 10th Aug. 2004