Drosophila Genomics and Genetic Resources

Date	:	October 15th - 16th, 2015,
Time	:	13:30-16:00
Location	:	Dept. Drosophila Genomics and Genetic Resources at Saga campus
Presenter	:	Dr. Brian Oliver Laboratory of Cellular and Developmental Biology NIDDK, NIH
Title	:	"Functional Genomics"
Abstract	:	We have learned a great deal about the logic of development and disease by studying transcription over the last several decades. The techniques have evolved from analysis of expression of single genes to rapidly evolving genome-wide techniques. We will focus on next generation sequencing and discuss elements of experimental design, the use of exogenous RNAs of known concentration as internal standards, and computational null models using simulations. There are many applications for expression analysis. These include the use of expression data for genome annotation to identify UTR extensions, novel exons, and novel genes, especially in the male transcriptome. Not every segment of transcribed DNA is functional. Operating under the assumption that functional elements will show conserved expression in the genus, we will illustrate the value of comparative gene expression profiling used to determine if novel transcribed segments in D. melanogaster were functional. Gene expression profiles are a molecular phenotype. We will discuss using expression phenotypes to address genome-wide questions, particularly about the nature and evolution of gene content and dosage compensation due to sexual selection, and as a valuable tool for building genetic pathways.

Chairperson

:

Tim Karr

For more infomation, contact: Takano, Toshiyuki
Dept. Drosophila Genomics and Genetic Resources
Tel. 075-873-2660
Please contact from this form.


このセミナーは平成27年度国際化モデル研究室に採択された「国際交流を起爆剤に推進する精子ゲノム学」事業の一環として実施するものです